The ESP Process

Exclusion-based Sample Preparation (ESP) is fundamentally different from traditional sample preparation processes. 


Before getting into how ESPTM works and what makes ESP different, let's discuss a key component of ESP: magnetic beads. In recent years, magnetic beads have become a staple reagent in sample prep and are readily available with a wide variety of surface modifications tailored to capture specific analytes. ESP leverages these "tried and true" workhorses in exciting new ways to enhance sample prep performance.


The difference between ESP and the other guys? We do it better. With ESP, we don't slide the beads along a surface - which can create shear resulting in loss of analyte - we immobilize them. We don't move the fluids - which can result in loss of precious sample - we preserve them. What does this mean? Beads are handled gently and fluids are left untouched to make sure we get the most out of precious samples.


The anatomy of ESP and our use of microscale phenomena make this possible. ESP leverages convex droplets that are held in place by surface tension and geometric constrictions. We use hydrophobic surfaces and unique designs to limit carryover and preserve samples for continued interrogation. Click here to see examples of ESPTM in action.